Building Atlases of Heart Wall Fibers
Professor Kaleem Siddiqi, School of Computer Science and the Centre for Intelligent Machines, McGill University
Prof. K. Siddiqi
Sep 13, 2013
from 02:30 PM to 03:30 PM
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Studies of cardiac fiber variability within a species tend to focus on first-order measures such as local fiber orientation. Recent work has shown that myofibers bundle locally into a particular type of minimal surface, the generalized helicoid model (GHM), which is described by three biologically meaningful curvature parameters. In order to allow comparisons between species, a typical strategy is to divide the parameters of the generalized helicoid by heart wall diameter. This normalization does not compensate for variability in myocardial shape between subjects and makes the interpretation of results difficult. We propose to use several myocardial atlases, obtained using diffeomorphic groupwise Log-demons, to register all hearts to a common reference shape to perform the normalization. In this common space, the GHM is estimated for all hearts and compared using an improved fitting method. Our results demonstrate improved consistency between GHM curvatures within a species and support a direct relation between myocardial shape and fiber curvature in the heart.
Joint work with Emmanuel Piuze, Hervé Lombaert, Jon Sporring, A. J. Bakermans and Gustav Strijkers.
P. Savadjiev, G. J. Strijkers, A. J. Bakermans, E. Piuze, S. W. Zucker & K. Siddiqi
Heart Wall Myofibers are Arranged in Minimal Surfaces to Optimize Organ Function.
Proceedings of the National Academy of Science, 109(24):9248-9253, 2012. © 2012 by PNAS
E. Piuze, J. Sporring & K. Siddiqi
Moving Frames for Heart Fiber Geometry.
Proceedings of Information Processing in Medical Imaging, 2013. © 2013 by Springer.
E. Piuze, H. Lombaert, J. Sporring & K. Siddiqi
Cardiac Fiber Inpainting using Maurer-Cartan Forms.
International Conference On Medical Image Computing and Computer Assisted Intervention (Nagoya, Japan), 2013.
E. Piuze, H. Lombaert, J. Sporring, G. Strijkers, A. Bakermans & K. Siddiqi
Atlases of Cardiac Fiber Differential Structure.
International Conference On Functional Imaging and Modeling of the Heart (London, UK) , 2013. © 2013 by Springer.
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